• (S)-Mephenytoin in CYP2C19 Drug Metabolism: Advanced In V...

  2025-10-20

  (S)-Mephenytoin serves as a definitive CYP2C19 substrate for oxidative drug metabolism studies. Explore its mechanistic role, integration with hiPSC-derived organoid models, and the next frontier in in vitro pharmacokinetics, uniquely bridging enzyme kinetics with translational research.

• Elevating Translational Research: Mechanistic Insights an...

  2025-10-19

  This thought-leadership article offers translational researchers a mechanistic and strategic roadmap for deploying Cell Counting Kit-8 (CCK-8) in advanced cell viability, proliferation, and cytotoxicity assays. Integrating the latest findings in single-cell analytics, mitochondrial function, and cellular heterogeneity, we contextualize CCK-8’s unique advantages in the evolving landscape of sensitive, scalable, and clinically relevant cell-based assays. Distinct from standard product overviews, this piece provides a forward-looking synthesis tied to practical guidance, emerging applications, and the imperative of robust, reproducible data for translational medicine.

• (S)-Mephenytoin: Precision CYP2C19 Substrate for Organoid...

  2025-10-18

  (S)-Mephenytoin empowers researchers with robust, human-relevant pharmacokinetic insights by serving as the gold-standard CYP2C19 substrate in hiPSC-derived intestinal organoid models. Its precision in profiling oxidative drug metabolism and decoding genetic polymorphisms sets it apart from traditional assay tools. Unlock advanced troubleshooting strategies and protocol enhancements to maximize data quality and translational value.

• HyperScribe™ Poly (A) Tailing Kit: Advancing Precision RN...

  2025-10-17

  Explore how the HyperScribe™ Poly (A) Tailing Kit enables precise polyadenylation of RNA transcripts to enhance mRNA stability and translation efficiency. This article uniquely delves into the kit’s impact on advanced functional metabolic research and post-transcriptional RNA processing.

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